Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. kidney problems-little or no urinating, swelling in your feet or ankles, feeling tired or short of breath.When a single 40 mg dose of atorvastatin was coadministered with 240 mL of grapefruit juice, atorvastatin peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 16 and 37, respectively. Severe side effects are rare, but can include muscle fiber breakdown and kidney injury. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
Atorvastatin and grapefruit juice side effects skin#
liver problems-upper stomach pain, weakness, tired feeling, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes) or Side effects from grapefruit-statin interaction are typically mild, such as increase in muscle and joint pain.trouble lifting your arms, trouble climbing or standing.muscle weakness in your hips, shoulders, neck, and back.Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.Īlso call your doctor at once if you have: In rare cases, atorvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Get emergency medical help if you have signs of an allergic reaction: hives difficulty breathing swelling of your face, lips, tongue, or throat. Side Effects What are the side effects of Lipitor (Atorvastatin)?
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